Symbol
Name
ID

Brca2
breast cancer 2, early onset
MGI:109337

Phenotype annotations related to endocrine/exocrine glands

Darker colors indicate more annotations

Human Phenotypes	Diabetes mellitus	Exocrine pancreatic insufficiency	Pancreatic adenocarcinoma	Abnormality of the hypothalamus-pituitary axis	Hypogonadism
Disease(s) Associated with BRCA2	Diabetes mellitus	Exocrine pancreatic insufficiency	Pancreatic adenocarcinoma	Abnormality of the hypothalamus-pituitary axis	Hypogonadism
Fanconi anemia
pancreatic cancer

Mouse Phenotypes

exocrine pancreatic insufficiency

adrenal gland hyperplasia

increased thymus weight

abnormal branching of the mammary ductal tree

decreased mammary duct terminal end bud number

increased mammary gland tumor incidence

increased mammary adenocarcinoma incidence

prostate gland hyperplasia

absent ovarian follicles

small ovary

ovary degeneration

small testis

increased prostate intraepithelial neoplasia incidence

increased T cell derived lymphoma incidence

abnormal prostate gland physiology

Availability

Mouse Genotype

Brca2^tm1Cam/Brca2^tm1Cam

Brca2^tm1Cbl/Brca2^tm1Cbl

Brca2^tm1Kamc/Brca2^tm1Kamc

Brca2^tm1Mbn/Brca2⁺

Brca2^tm2.1Sks/Brca2^tm1Brd

Brca2^tm1Brn/Brca2^tm1Brn
Tg(Pbsn-cre)4Prb/0 (conditional)

Brca2^tm2Arge/Brca2^tm2Arge
Wap^tm1(cre)Arge/Wap^tm1(cre)Arge (conditional)

Brca2^tm1Arge/Brca2^tm2Arge
Wap^tm1(cre)Arge/Wap⁺ (conditional)

Brca2^tm1Cam/Brca2^tm1Brn
Tg(Pdx1-cre)6Tuv/0 (conditional)

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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